Disruption of the gut microbiota and intestinal function can trigger immune states in the horse and disrupts signalling of the gut brain axis.
As a result leaky gut and other inflammatory disorders of the gastrointestinal tract will lead to inflammation in the central nervous system.
Loss of stability in the gut will create microbiota disease, abnormal gut functions lead to an increase of inflammatory mediators, that visceral pain also alters behaviour and affects the locomotive of the horse. These changes include dentretic hypertrophy in pain related brain areas and the amygdala which is part of the brain also associated with fear and anxiety.
The area of the brain affected by microbial deficiencies include the hippocampus which is critical for learning and memory.
Stress and microbial disruption decreases brain derived neuropathic factor (BDNF) also leads to abnormal development.
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